Knee and Hip arthritis are considered as one of the main causes of functional disability in humans. The patient with arthritis is suffering not only from the persistent pain, stiffness and limited mobility, moreover, it also directly affects their quality of life.
Recommendations for osteoarthritis hip treatment & knee and management includes non-pharmacological such as patient education and awareness, physical exercise and rehabilitation aids.
The pharmacological modalities vary from prescription of non-selective NSAIDs (Nonsteroidal anti-inflammatory drugs) and selective COX-2 inhibitors agents and in some cases even opioid type medication. NSAIDs are the most prescribed medicine for osteoarthritis. Despite NSAIDs established effectiveness in relieving the pain with osteoarthritis, its long-term use is associated with potentially harmful adverse effects.
The other potential non-operative therapeutic methods are chondroitin sulfate, glucosamine, and intra-articular injections of visco-supplements, corticosteroids, or blood-derived products. Over the last decades, there is an ongoing trend to use Intra-articular injections of either corticosteroids, analgesics/anti-inflammatory drugs, polymerized collagen, anti-cytokine drugs, or hyaluronic acid as alternative modalities to maximize the topical effect and minimize the systemic adverse effects. Each injection has been shown to lower the pain in patients in some form, though hyaluronic acid treatments using Duralane® seem to be amongst the safest and effective.